Dolutegravir-induced liver injury leading to sub-acute liver failure requiring transplantation: a case report and review of literature.
Bo WangLaura AbbottKate ChildsChris TaylorKosh AgarwalIan CormackRosa MiquelAbid SuddlePublished in: International journal of STD & AIDS (2017)
A patient with human immunodeficiency virus-1 infection presented with sub-acute liver failure, temporally related to commencement of an antiretroviral therapy regimen containing dolutegravir (Triumeq). The patient was not a carrier of HLA-B5701, and abacavir hypersensitivity was unlikely. We believe this is the first report of severe dolutegravir-related hepatotoxicity resulting in sub-acute liver failure and transplantation and highlights a potential need for closer monitoring after drug initiation.
Keyphrases
- liver failure
- antiretroviral therapy
- hepatitis b virus
- hiv infected patients
- hiv infected
- drug induced
- human immunodeficiency virus
- hiv positive
- case report
- hiv aids
- endothelial cells
- emergency department
- intensive care unit
- bone marrow
- risk assessment
- mesenchymal stem cells
- early onset
- adverse drug
- men who have sex with men
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome
- south africa
- mechanical ventilation