Syk promotes phagocytosis by inducing reactive oxygen species generation and suppressing SOCS1 in macrophage-mediated inflammatory responses.

Young-Su YiHan Gyung KimJi Hye KimWoo Seok YangEunji KimJae Gwang ParkNur AzizNarayanan ParameswaranYoung-Jin Son

Published in: International journal of immunopathology and pharmacology (2022)

These results suggest that Syk plays a critical role in the phagocytic activity of macrophages by inducing ROS generation and suppressing SOCS1 through SOCS1 nitration during inflammatory responses.

Keyphrases

reactive oxygen species
tyrosine kinase
signaling pathway
dna damage
cell death