Low mitochondrial DNA copy number induces chemotherapy resistance via epithelial-mesenchymal transition by DNA methylation in esophageal squamous cancer cells.

Yuto KuboKoji TanakaYasunori MasuikeTsuyoshi TakahashiKotaro YamashitaTomoki MakinoTakuro SaitoKazuyoshi YamamotoTomoyuki TsujimotoTakashi HarinoYukinori KurokawaMakoto YamasakiKiyokazu NakajimaHidetoshi EguchiYuichiro Doki

Published in: Journal of translational medicine (2022)

This study showed that decreased mtDNA copy number induced EMT via modulation of MMP and DNA methylation in ESCC. Therapeutic strategies increasing mtDNA copy number and DNMT inhibitors may be effective in preventing EMT and chemosensitivity resistance.

Keyphrases

copy number
dna methylation
mitochondrial dna
epithelial mesenchymal transition
genome wide
transforming growth factor
gene expression
signaling pathway
high glucose
high grade
diabetic rats