Hydronidone induces apoptosis in activated hepatic stellate cells through endoplasmic reticulum stress-associated mitochondrial apoptotic pathway.
Zhongshang SunYuecheng GuoXianjun XuCui ZhouXin LuoZhenyang ShenBo ShenJunjun WangJingyi LuQingqing ZhangFeifei ShenLou YuYanping YeLing ZhangYing LuoYing QuXiaobo CaiHui DongLun Gen LuPublished in: Journal of gastroenterology and hepatology (2024)
The findings of both in vivo and in vitro studies suggest that HDD induces apoptosis in aHSCs via the ERS-associated mitochondrial apoptotic pathway, potentially contributing to the amelioration of liver fibrosis.