Type 2 Diabetes risk alleles in Peptidyl-glycine Alpha-amidating Monooxygenase influence GLP-1 levels and response to GLP-1 Receptor Agonists.

Mahesh M UmapathysivamElisa AraldiBenoit HastoyAdem Y DawedHasan VatandaslarShahana SenguptaAdrian KaufmannSøren ThomsenBolette HartmannAnna E JonssonHasan KabakciSwaraj ThamanNiels GrarupChristian T HaveKristine FærchAnette P GjesingSameena NawazJane CheesemanMatthew J NevilleOluf PedersenMark WalkerChristopher JennisonAndrew T HattersleyTorben HansenFredrik KarpeJens J HolstAngus G JonesMichael RistowMark I McCarthyEwan R PearsonMarkus StoffelAnna L Gloyn

Published in: medRxiv : the preprint server for health sciences (2023)

has effects on incretin signaling that alters response to medication used commonly for treatment of T2D.

Keyphrases

type diabetes
healthcare
glycemic control
combination therapy
electronic health record
drug induced