ARPC5 is transcriptionally activated by KLF4, and promotes cell migration and invasion in prostate cancer via up-regulating ADAM17 : ARPC5 serves as an oncogene in prostate cancer.

GenYi QuYuLong ZhangHongTao DuanCheng TangGuang YangDan ChenYong Xu

Published in: Apoptosis : an international journal on programmed cell death (2023)

Collectively, ARPC5 was activated by KLF4 and upregulated ADAM17 to promote PCa progression, which might act as a promising therapeutic target and prognostic biomarker for PCa.

Keyphrases

prostate cancer
radical prostatectomy
transcription factor
single cell
cell therapy