Ligand-Enabled Palladium(II)-Catalyzed γ-C(sp 3 )-H Arylation of Primary Aliphatic Amines.

The Pd(II)/sulfoxide-2-hydroxypyridine catalytic system shows promising activity in C-H activation chemistry. In this study, we showcase how this catalytic system solves the problem of native primary amine-directed γ-C(sp 3 )-H arylation. Primary amines with different complexities are compatible with the established methodology, and the range of applicable substrates can be expanded to include pyridine, oxime ether, and pyridine N -oxide.