Relation between microRNA-21, transforming growth factor β and response to treatment among chronic hepatitis C patients.
Amany A GhazyEman M OsmanEman A RashwanAhmed H GaballahHanan MostafaSalwa TawfikPublished in: Journal of medical virology (2019)
Nearly all responders to direct antiviral drugs showed increased levels of both miRNA-21 and TGF-β1. This may indicate an interplay between TGF-β1 and miRNA-21 during remission or progression of viral infection. Thus miRNA-21 could be used as promising serum biomarker, for assessment of antiviral treatment efficacy and improvement of fibrosis among chronically infected HCV patients.
Keyphrases
- transforming growth factor
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- epithelial mesenchymal transition
- prognostic factors
- peritoneal dialysis
- signaling pathway
- systemic lupus erythematosus
- human immunodeficiency virus
- patient reported
- combination therapy
- replacement therapy
- smoking cessation