Topical application of Chinese herbal medicine DAEP relieves the osteoarthritic knee pain in rats.

Wing Sum SiuWai Ting ShumWen ChengChun Wai WongHoi Ting ShiuChun Hay KoPing Chung LeungChristopher Wai Kei LamChun-Kwok Wong

Published in: Chinese medicine (2019)

DAEP exhibited its effect via the nuclear factor (NF)-κB pathway by suppressing the phosphorylation of IκB kinase αβ (p-IKKαβ) and cyclooxygenase-2 (COX-2) protein expression. This study provides scientific evidence to support the clinical application of the Chinese herbal paste on reliving OA pain.

Keyphrases

nuclear factor
chronic pain
toll like receptor
pain management
neuropathic pain
knee osteoarthritis
protein kinase
total knee arthroplasty
signaling pathway
lps induced
inflammatory response
immune response
nitric oxide synthase
mass spectrometry
high resolution