Combination of AKT1 and CDH1 mutations predicts primary resistance to immunotherapy in dMMR/MSI-H gastrointestinal cancer.

Zhenghang WangQi ZhangChangsong QiYuezong BaiFeilong ZhaoHui ChenZhongwu LiXicheng WangMifen ChenJifang GongZhi PengXiaotian ZhangJinping CaiShiqing ChenXiaochen ZhaoLin ShenJian Li

Published in: Journal for immunotherapy of cancer (2022)

IOpred was identified as a powerful predictor of primary resistance to ICIs in dMMR/MSI-H GI cancer, which might serve as a promising biomarker to help guide immunotherapy decision-making.

Keyphrases

papillary thyroid
decision making
squamous cell
signaling pathway
cell proliferation
squamous cell carcinoma