Investigation of the Role of Neurokinin-1 Receptor Inhibition Using Aprepitant in the Apoptotic Cell Death through PI3K/Akt/NF-κB Signal Transduction Pathways in Colon Cancer Cells.

Atefeh Ghahremanloo Dr Hossein Javid Amir R Afshari Seyed Isaac Hashemy

Published in: BioMed research international (2021)

Towards this end, this study suggests that SP/NK1R system plays a vital role in the development of CRC, and pharmaceutical targeting of NK1R using aprepitant might be a promising treatment against CRC.

Keyphrases

pi k akt
cell death
cell cycle arrest
signaling pathway
cell proliferation
nk cells
lps induced
anti inflammatory
binding protein