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The Role of Low-Level Laser Therapy in Bone Healing: Systematic Review.

Micaela BerniAlice Maria BrancatoCamilla TorrianiValentina BinaSalvatore AnnunziataElena CornellaMichelangelo TrucchiEugenio JannelliMario MosconiGiulia GastaldiLaura CaliognaFederico Alberto GrassiGianluigi Pasta
Published in: International journal of molecular sciences (2023)
Low-level laser therapy (LLLT) is a treatment that is increasingly used in orthopedics practices. In vivo and in vitro studies have shown that low-level laser therapy (LLLT) promotes angiogenesis, fracture healing and osteogenic differentiation of stem cells. However, the underlying mechanisms during bone formation remain largely unknown. Factors such as wavelength, energy density, irradiation and frequency of LLLT can influence the cellular mechanisms. Moreover, the effects of LLLT are different according to cell types treated. This review aims to summarize the current knowledge of the molecular pathways activated by LLLT and its effects on the bone healing process. A better understanding of the cellular mechanisms activated by LLLT can improve its clinical application.
Keyphrases
  • systematic review
  • stem cells
  • healthcare
  • bone mineral density
  • cell therapy
  • primary care
  • meta analyses
  • body composition
  • newly diagnosed
  • wound healing
  • case control