A Study on the Chemistry and Biological Activity of 26-Sulfur Analogs of Diosgenin: Synthesis of 26-Thiodiosgenin S -Mono- and Dioxides, and Their Alkyl Derivatives.

Aneta M Tomkiel Dorota Czajkowska-SzczykowskaEwa Olchowik-GrabarekLucie RárováSzymon SękowskiJacek W Morzycki

Published in: Molecules (Basel, Switzerland) (2022)

A chemoselective procedure for MCPBA oxidation of 26-thiodiosgenin to corresponding sulfoxides and sulfone was elaborated. An unusual equilibration of sulfoxides in solution was observed. Moreover, α-alkylation of sulfoxide and sulfone was investigated. Finally, the biological activity of obtained compounds was examined.

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