Adherence to Antiretroviral Therapy and Associated Factors Among People Living With HIV Following the Introduction of Dolutegravir Based Regimens in Dar es Salaam, Tanzania.
Mary Spicar KilapiloRaphael Zozimus SangedaGeorge M BwireGodfrey Leonard SambayiIdda Hubert MoshaJaphet KillewoPublished in: Journal of the International Association of Providers of AIDS Care (2022)
Background: Adherence to antiretroviral therapy (ART) is the key determinant of virological suppression in people living with HIV (PLHIV). This study reports factors associated with non-adherence among PLHIV one year after introducing dolutegravir (DTG) based regimens in Tanzania. Methods: A hospital-based cross-sectional study was conducted in two health facilities in Dar es Salaam, Tanzania, in 2020. Results: A total of 406 PLHIV were recruited, where the majority (73.4%) were females, with 94.6% of patients being on DTG based regimens. Factors such as refill interval and sharing of antiretrovirals had significant effects on adherence. Multivariate analysis found that patients attending care and treatment center (CTC) at Temeke Regional Referral Hospital (RRH) were 4.3 times more likely to have non-adherence compared to those attending Amana RRH (aOR [adjusted odds ratio] 4.3, 95% CI [confidence interval]: 2.38 - 7.91, p-value < 0.0001). Conclusions: Sustainable adherence counseling is warranted to overcome non-adherence to ART.
Keyphrases
- antiretroviral therapy
- hiv infected
- hiv infected patients
- end stage renal disease
- human immunodeficiency virus
- healthcare
- hiv aids
- hiv positive
- ejection fraction
- chronic kidney disease
- newly diagnosed
- glycemic control
- peritoneal dialysis
- primary care
- palliative care
- social media
- adverse drug
- insulin resistance
- climate change
- hiv testing
- pain management
- south africa
- circulating tumor cells
- drug induced