Activated sputum eosinophils associated with exacerbations in children on mepolizumab.

Gabriella E WilsonJames KnightQing LiuAshish ShelarEmma StewartXiaomei WangXiting YanJoshua SandersCynthia VisnessMichelle GillRebecca GruchallaAndrew H LiuMeyer KattanGurjit K Khurana HersheyAlkis TogiasPatrice M BeckerMatthew C AltmanWilliam W BusseDaniel J JacksonRuth R MontgomeryGeoffrey L Chupp

Published in: The Journal of allergy and clinical immunology (2024)

eosinophils were significantly elevated in children on mepolizumab who had exacerbations, suggesting that eosinophil subpopulations exist that contribute to exacerbations despite anti-IL-5 treatment.

Keyphrases

cystic fibrosis
chronic obstructive pulmonary disease
young adults
mycobacterium tuberculosis
pulmonary tuberculosis
combination therapy