A cooling-driven self-adaptive and removable hydrogel coupled with combined chemo-photothermal sterilization for promoting infected wound healing.
Jun CaoTao ZhangWei ZhuHou-Bin LiAi-Guo ShenPublished in: Nanoscale (2023)
Hydrogel dressings that can fit irregular wounds, promote wound healing, and detach from wounds without damage represent the development trend of modern medical dressings. Herein, a novel composite hydrogel with excellent wound shape matching and painless removability via a gel-sol phase transition is constructed through dynamic borate ester bonds between phenylboronic acid-grafted F127 (PF127) and polydopamine-coated reduced graphene oxide/silver nanoparticles (rGO@PDA/Ag NPs). After contact with the skin tissues, the administered liquid-like sols gradually transform into solid-like gels, robustly adhering to the wound. The hydrogel dressings containing near-infrared (NIR)-responsive rGO@PDA and in situ formed Ag NPs can generate localized heat and gradually release Ag + to realize safe, effective, and durable photothermal-chemical combined sterilization. In addition, catechol-rich PDA endows the hydrogel dressings with good antioxidant activity and adhesiveness. In vivo study results indicate that the hydrogel dressings can significantly accelerate full-thickness skin infected wound healing by eliminating bacteria, promoting collagen deposition and angiogenesis, as well as reducing inflammation. Collectively, the thermoreversible rGO@PDA/Ag-PF127 hydrogel dressings with an improved self-adapting ability, superior antimicrobial activity, and tunable adhesion appear to be a promising candidate for the treatment of infected wounds.
Keyphrases
- wound healing
- reduced graphene oxide
- photodynamic therapy
- quantum dots
- drug delivery
- cancer therapy
- gold nanoparticles
- healthcare
- visible light
- oxidative stress
- silver nanoparticles
- highly efficient
- escherichia coli
- gene expression
- drug release
- ionic liquid
- radiation therapy
- optical coherence tomography
- squamous cell carcinoma
- vascular endothelial growth factor
- endothelial cells
- hyaluronic acid
- smoking cessation
- replacement therapy