Acute effects of Δ9-tetrahydrocannabinol and cannabidiol on auditory mismatch negativity.

Lisa-Marie GreenwoodSamantha J BroydHendrika H van HellJuanita ToddAlison JonesRobin M MurrayRodney J CroftPatricia T MichieNadia Solowij

Published in: Psychopharmacology (2021)

The pattern of effects following CBD combined with THC on MMN may be subserved by different underlying neurobiological interactions within the endocannabinoid system that vary as a function of prior cannabis exposure. These results highlight the complex interplay between the acute effects of exogenous cannabinoids and NMDAR function. Further research is needed to determine how this process normalises after the acute effects dissipate and following repeated acute exposure.

Keyphrases

liver failure
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aortic dissection
working memory
intensive care unit
mechanical ventilation
acute respiratory distress syndrome