Regulation of carbohydrate degradation pathways in Pseudomonas involves a versatile set of transcriptional regulators.
Zulema UdaondoJuan Luis RamosAna SeguraTino KrellAbdelali DaddaouaPublished in: Microbial biotechnology (2018)
Bacteria of the genus Pseudomonas are widespread in nature. In the last decades, members of this genus, especially Pseudomonas aeruginosa and Pseudomonas putida, have acquired great interest because of their interactions with higher organisms. Pseudomonas aeruginosa is an opportunistic pathogen that colonizes the lung of cystic fibrosis patients, while P. putida is a soil bacterium able to establish a positive interaction with the plant rhizosphere. Members of Pseudomonas genus have a robust metabolism for amino acids and organic acids as well as aromatic compounds; however, these microbes metabolize a very limited number of sugars. Interestingly, they have three-pronged metabolic system to generate 6-phosphogluconate from glucose suggesting an adaptation to efficiently consume this sugar. This review focuses on the description of the regulatory network of glucose utilization in Pseudomonas, highlighting the differences between P. putida and P. aeruginosa. Most interestingly, It is highlighted a functional link between glucose assimilation and exotoxin A production in P. aeruginosa. The physiological relevance of this connection remains unclear, and it needs to be established whether a similar relationship is also found in other bacteria.
Keyphrases
- pseudomonas aeruginosa
- biofilm formation
- plant growth
- cystic fibrosis
- amino acid
- candida albicans
- transcription factor
- blood glucose
- end stage renal disease
- staphylococcus aureus
- acinetobacter baumannii
- newly diagnosed
- ejection fraction
- lung function
- chronic kidney disease
- escherichia coli
- gene expression
- microbial community
- blood pressure
- prognostic factors
- type diabetes
- metabolic syndrome
- patient reported outcomes
- air pollution
- network analysis