Mechanism of Fructus Mume Pills Underlying Their Protective Effects in Rats with Acetic Acid-Inducedulcerative Colitis via the Regulation of Inflammatory Cytokines and the VEGF-PI3K/Akt-eNOS Signaling Pathway.

Zongying XuXueli ZhangRuimin LuDi ZhangTianyuan ZouMeng Chen Dongmei Zhang

Published in: Evidence-based complementary and alternative medicine : eCAM (2022)

These results suggest that FMPs control UC inflammation by regulating inflammatory cytokine concentrations. FMPs alleviate AA-induced UC by regulating microvascular permeability through the VEGF-PI3K/Akt-eNOS signaling pathway.

Keyphrases

pi k akt
signaling pathway
endothelial cells
high glucose
vascular endothelial growth factor
oxidative stress
cell cycle arrest
cell proliferation
diabetic rats
epithelial mesenchymal transition
induced apoptosis
drug induced
nitric oxide
ulcerative colitis