A Case-Control Study by ddPCR of ALU 260/111 and LINE-1 266/97 Copy Number Ratio in Circulating Cell-Free DNA in Plasma Revealed LINE-1 266/97 as a Potential Biomarker for Early Breast Cancer Detection.
Marina BortulFabiola GiudiciDomenico TiernoDaniele GeneraliSerena ScomersiGabriele GrassiCristina BottinMaria Rosa CappellettiFabrizio ZanconatiBruna ScaggiantePublished in: International journal of molecular sciences (2023)
Analysis of LINE-1 266/97 copy number ratio or cfDI by ddPCR appears to be a useful noninvasive test that could aid in early BC detection. Further studies in a large cohort are needed to validate the biomarker.