An Organotypic Human Lymph Node Model Reveals the Importance of Fibroblastic Reticular Cells for Dendritic Cell Function.

Andrew I MorrisonAleksandra M MikulaSander W Spiekstra Michael de Kok Alsya A AffandiHenk P RoestLuc J W van der Laan Charlotte M de Winde Jasper J Koning Susan Gibbs Reina E Mebius

Published in: Tissue engineering and regenerative medicine (2023)

This 3D FRC-DC organotypic model highlights the influence and importance of FRCs for DC functioning in a more realistic HuLN microenvironment. As such, this work provides a starting point for the development of an in vitro HuLN.

Keyphrases

lymph node
induced apoptosis
dendritic cells
stem cells
cell cycle arrest
cell death
oxidative stress
immune response
signaling pathway