Chronic exposure to tumor necrosis factor alpha induces retinal pigment epithelium cell dedifferentiation.
Sarah TouhamiFanny BeguierSébastien AugustinHugo Charles-MessanceLucile VignaudEmeline F NandrotSacha ReichmanValérie ForsterThibaud MathisJosé-Alain SahelBahram BodaghiXavier GuillonneauFlorian SennlaubPublished in: Journal of neuroinflammation (2018)
Our results indicate that chronic TNFα-exposure is sufficient to alter RPE morphology and impede cardinal features that define the differentiated state of RPE cells with striking similarities to the alterations that are observed with age in neurodegenerative diseases such as age-related macular degeneration.