Heterogeneity in relaxation rate improves the synchronization of oscillatory neurons in a model of the SCN.

The circadian rhythms in mammals, that are regulated by the suprachiasmatic nucleus (SCN) of the brain, have been observed even in the absence of a light-dark cycle. The SCN is composed of about 10 000 autonomous neuronal oscillators, which are heterogenous in many oscillatory properties, including the heterogeneity in relaxation rates. Although the relaxation rate affects the entrainability of the SCN as a whole, not much is known about the reasons why the heterogeneity in relaxation rate exists. In the present study, based on a Poincaré model, we examine whether the heterogeneity in the relaxation rate affects the synchronization of the SCN neuronal oscillators under constant darkness. Both our simulations and theoretical results show that the heterogeneity improves the synchronization. Our findings provide an alternative explanation for the existence of the heterogeneity in the SCN neurons and shed light on the effect of neuronal heterogeneity on the collective behavior of the SCN neurons.