Amylin Analog Pramlintide Induces Migraine-like Attacks in Patients.

Hashmat Ghanizada Mohammad Al-Mahdi Al-KaragholiChristopher S WalkerNanna ArngrimTayla ReesJakeb PetersenAndrew SiowMette Mørch-RasmussenSheryl TanSimon J O'CarrollPaul HarrisLene Theil SkovgaardNiklas Rye JørgensenMargaret BrimbleJayme S WaiteBrandon J ReaLevi P SowersAndrew F RussoDebbie L HayMessoud Ashina

Published in: Annals of neurology (2021)

Our findings propose amylin receptor agonism as a novel contributor to migraine pathogenesis. Greater therapeutic gains could therefore be made for migraine patients through dual amylin and CGRP receptor antagonism, rather than selectively targeting the canonical CGRP receptor. ANN NEUROL 2021;89:1157-1171.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
patient reported outcomes
drug delivery
binding protein