New Series of VEGFR-2 Inhibitors and Apoptosis Enhancers: Design, Synthesis and Biological Evaluation.

Abdallah E AbdallahReda R MabroukMohamed R ElnagarAmel Mostafa FarragMohamed H KalabaMohamed H SharafEsmail M El-Fakharany Dina Abed Bakhotmah Eslam B Elkaeed Maged Mohammed Saleh Al Ward

Published in: Drug design, development and therapy (2022)

is a very significant anticancer candidate, and piperazinylquinoxaline is an important scaffold in the development of new potential effective and safer VEGFR-2 inhibitor agents.

Keyphrases

vascular endothelial growth factor
oxidative stress
endoplasmic reticulum stress
cell cycle arrest
cell death
human health
cell proliferation
endothelial cells