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Association between ALDH2 Polymorphism and Gastric Cancer Risk in a Korean Population.

Chang Kyun ChoiSun Seog KweonSang Hee ChoHye Yeon KimMin-Ho Shin
Published in: Journal of Korean medical science (2020)
The association between alcohol and gastric cancer is stronger in East Asians than in other ethnic groups, presumably due to an aldehyde dehydrogenase 2 (ALDH2) polymorphism. Therefore, we investigated the relationship between the ALDH2 rs671 polymorphism and gastric cancer in a Korean population. This case-control study included 3,245 hospital patients newly diagnosed with gastric cancer and 8,732 population controls. The ALDH2 rs671 genotype was classified as inactive ALDH2 (GG) or active ALDH2 (GA/AA). The risk of gastric cancer was higher in men with the inactive ALDH2 than in those with active ALDH2 (odds ratio [OR], 1.25; 95% confidence interval [CI], 1.09-1.39), whereas no significant association was found between ALDH2 genotype and gastric cancer in women (OR, 1.00; 95% CI, 0.99-1.02). In men, the association between ALDH2 genotype and gastric cancer was stronger in current drinkers. Our findings support the previously reported association between inactive ALDH2 and high risk of gastric cancer.
Keyphrases
  • newly diagnosed
  • end stage renal disease
  • healthcare
  • chronic kidney disease
  • emergency department
  • metabolic syndrome
  • pregnant women
  • insulin resistance
  • high resolution
  • peritoneal dialysis
  • cancer stem cells