Inflammatory Activity of Epithelial Stem Cell Variants from Cystic Fibrosis Lung Is Not Resolved by CFTR Modulators.

Shan WangSuchan NiroulaAshley HoffmanMelika KhorramiMelina KhorramiFeng YuanGrace N GasserSoon ChoiBovey LiuJustin LiMark L MeterskyMatthew VincentChristopher P CrumRichard C BoucherHarry Karmouty-QuintanaHoward J HuangAjay SheshadriBurton F DickeyKalpaj R ParekhJohn F EngelhardtFrank D McKeonWa Xian

Published in: American journal of respiratory and critical care medicine (2023)

The emergence of proinflammatory stem cell variants in CF lung may explain the persistence of lung inflammation in CF patients undergoing CFTR modulator therapy.

Keyphrases

cystic fibrosis
stem cells
pseudomonas aeruginosa
lung function
patients undergoing
oxidative stress
copy number
small molecule
gene expression
cell therapy
dna methylation
chronic obstructive pulmonary disease
mesenchymal stem cells
genome wide