Paeoniflorin Alleviates Anxiety and Visceral Hypersensitivity via HPA Axis and BDNF/TrkB/PLCγ1 Pathway in Maternal Separation-induced IBS-like Rats.
Rui-Feng LiangWenjing GeXianmei SongHuisen WangWeifeng CuiXuexia ZhangZheng WeiGengsheng LiPublished in: Current molecular pharmacology (2024)
These findings suggest that PF alleviated anxiety and visceral hypersensitivity in MS-induced IBS-like rats, which may be the modulation of HPA axis activity and BDNF/TrkB/PLCγ1 signaling pathway.
Keyphrases
- drug induced
- signaling pathway
- high glucose
- diabetic rats
- insulin resistance
- mass spectrometry
- multiple sclerosis
- sleep quality
- irritable bowel syndrome
- stress induced
- type diabetes
- endothelial cells
- metabolic syndrome
- induced apoptosis
- body mass index
- depressive symptoms
- cell proliferation
- endoplasmic reticulum stress