Depsidomycins B and C: New Cyclic Peptides from a Ginseng Farm Soil-Derived Actinomycete.
Yun KwonWoong Sub ByunByung-Yong KimMyoung Chong SongMunhyung BaeYeo Joon YoonJongheon ShinSang Kook LeeDong-Chan OhPublished in: Molecules (Basel, Switzerland) (2018)
LC/MS-based chemical profiling of a ginseng farm soil-derived actinomycete strain, Streptomyces sp. BYK1371, enabled the discovery of two new cyclic heptapeptides, depsidomycins B and C (1 and 2), each containing two piperazic acid units and a formyl group at their N-terminus. The structures of 1 and 2 were elucidated by a combination of spectroscopic and chemical analyses. These new compounds were determined to possess d-leucine, d-threonine, d-valine, and S-piperazic acid based on the advanced Marfey's method and a GITC (2,3,4,6-tetra-O-acetyl-β-d-glucopyranosyl isothiocyanate) derivatization of their hydrolysates, followed by LC/MS analysis. Depsidomycins B and C displayed significant antimetastatic activities against metastatic breast cancer cells (MDA-MB-231).
Keyphrases
- breast cancer cells
- small cell lung cancer
- squamous cell carcinoma
- small molecule
- molecular docking
- ms ms
- high resolution
- liquid chromatography tandem mass spectrometry
- high performance liquid chromatography
- high throughput
- simultaneous determination
- gas chromatography mass spectrometry
- mass spectrometry
- amino acid
- cell death
- pi k akt