Reduced ELANE and SLPI expression compromises dental pulp cell activity.

Kanokwan Sriwattanapong Noppadol Sa-Ard-Iam Lawan Boonprakong Keskanya Subbalekha Vorapat Trachoo Narissara Suratannon Thantrira Porntaveetus Vorasuk Shotelersuk

Published in: Cell proliferation (2021)

This study, for the first time, suggests that in addition to neutropenia, the aberrant levels and functions of ELANE, SLPI and their downstream molecules in pulp cells play an important role in oral complications in SCN patients. In addition, pulp cells with diminished neutrophil elastase and SLPI are highly responsive to inflammation.

Keyphrases

induced apoptosis
cell cycle arrest
end stage renal disease
oxidative stress
ejection fraction
peritoneal dialysis
single cell
binding protein