Gestational changes in buprenorphine exposure: A physiologically-based pharmacokinetic analysis.
Hongfei ZhangHari Varun KalluriJaime R BastianHuijun ChenAli AlshabiSteve N CaritisRaman VenkataramananPublished in: British journal of clinical pharmacology (2018)
PBPK model-based simulation may be a useful tool to optimize BUP pharmacotherapy during pregnancy, obviating the need to perform pharmacokinetic studies in each trimester and the postpartum period that normally require intensive blood sampling.