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Gestational changes in buprenorphine exposure: A physiologically-based pharmacokinetic analysis.

Hongfei ZhangHari Varun KalluriJaime R BastianHuijun ChenAli AlshabiSteve N CaritisRaman Venkataramanan
Published in: British journal of clinical pharmacology (2018)
PBPK model-based simulation may be a useful tool to optimize BUP pharmacotherapy during pregnancy, obviating the need to perform pharmacokinetic studies in each trimester and the postpartum period that normally require intensive blood sampling.
Keyphrases
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  • pregnant women
  • pregnancy outcomes
  • preterm birth
  • smoking cessation
  • body mass index
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