Interleukin-2-based therapies in cancer.
Miro E RaeberDilara SahinOnur BoymanPublished in: Science translational medicine (2022)
Molecular insights into the mechanism of beneficial and adverse effects of interleukin-2 (IL-2) have resulted in the development of improved IL-2 formulations with IL-2 receptor bias and tissue-targeting properties. Several of these compounds are currently in clinical development and are ushering IL-2 therapy into the current era of cancer immunotherapy.