Tumor-derived exosomes drive pre-metastatic niche formation in lung via modulating CCL1 + fibroblast and CCR8 + Treg cell interactions.

Ming WangZhongyu QinJiajia WanYan YanXixi DuanXiaohan YaoZiming JiangWenqing LiZhihai Qin

Published in: Cancer immunology, immunotherapy : CII (2022)

Collectively, our study provides a novel mechanism by which Tregs are activated to form an immunologically tolerant PMN and demonstrates a critical link among lung fibroblasts, Tregs and metastatic tumor cells.

Keyphrases

squamous cell carcinoma
small cell lung cancer
mesenchymal stem cells
stem cells
single cell
dendritic cells
signaling pathway
regulatory t cells
liver injury
liver fibrosis
extracellular matrix
bone marrow