Drug-drug interactions between direct-acting antivirals and co-medications: a territory-wide cohort study.
Vicki Wing-Ki HuiChristopher Langjun AuAmy Shuk Man LamTerry Cheuk-Fung YipYee-Kit TseJimmy Che-To LaiHenry Lik-Yuen ChanVincent Wai-Sun WongGrace Lai-Hung WongPublished in: Hepatology international (2022)
The commonest co-medications leading to contraindication during DAA treatment were statins and antipsychotics. Category 2 and 3 DDIs are often managed by appropriate dose adjustments or temporary discontinuation of relevant co-medications. Careful assessment for potential DDI before DAA use is mandatory to avoid potential harmful effects.