Tetravalent Metal Ion Guests in Polyoxopalladate Chemistry: Synthesis and Anticancer Activity of [MO8Pd12(PO4)8]12- (M = SnIV, PbIV).
Peng YangTian MaZhongling LangSonja Misirlic-DencicAndjelka M IsakovicAttila Csaba BényeiMirjana B ČolovićIvanka MarkovicDanijela Z KrstićJosep-Maria PobletZheng-Guo LinUlrich KortzPublished in: Inorganic chemistry (2019)
The first two examples of polyoxopalladates(II) (POPs) containing tetravalent metal ion guests, [MO8Pd12(PO4)8]12- (M = SnIV, PbIV), have been prepared and structurally characterized in the solid state, solution, and gas phase. The interactions of the metal ion guests and the palladium-oxo shell were studied by theoretical calculations. The POPs were shown to possess anticancer activity by causing oxidative stress inducing caspase activation and consecutive apoptosis of leukemic cells.
Keyphrases
- induced apoptosis
- solid state
- oxidative stress
- cell cycle arrest
- endoplasmic reticulum stress
- cell death
- signaling pathway
- dna damage
- ischemia reperfusion injury
- pi k akt
- molecular dynamics
- acute myeloid leukemia
- molecular dynamics simulations
- diabetic rats
- visible light
- reduced graphene oxide
- gold nanoparticles
- heat stress