The role of ASXL1 mutations and ASXL1 CircRNAs in cancer.

Narges Jafarbeik-Iravani Sara Kolahdozan Rezvan Esmaeili

Published in: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals (2024)

circRNA have dual functions in combination with different proteins, being involved in both transcriptional activation and repression in a context-dependent manner. Moreover, studies indicate these genes play an important role in epithelial-mesenchymal transition (EMT) and metastasis. Ongoing research is aimed at determining this gene family's function in biological events.

Keyphrases

epithelial mesenchymal transition
transforming growth factor
papillary thyroid
signaling pathway
squamous cell
gene expression
genome wide
transcription factor
lymph node metastasis
case control
squamous cell carcinoma
childhood cancer
oxidative stress
dna methylation
young adults