IgG1-3 MuSK Antibodies Inhibit AChR Cluster Formation, Restored by SHP2 Inhibitor, Despite Normal MuSK, DOK7, or AChR Subunit Phosphorylation.

Michelangelo Cao Wei-Wei Liu Susan Maxwell Saif Huda Richard WebsterAmelia EvoliDavid Beeson Judith A CossinsAngela Vincent

Published in: Neurology(R) neuroimmunology & neuroinflammation (2023)

MuSK-IgG1-3 is pathogenic but seems to act through a noncanonical pathway. Further studies should throw light on the mechanisms involved at the neuromuscular junction.

Keyphrases

protein kinase
case control