Targeting PDE4B (Phosphodiesterase-4 Subtype B) for Cardioprotection in Acute Myocardial Infarction via Neutrophils and Microcirculation.
Qing WanChuansheng XuLiyuan ZhuYuze ZhangZekun PengHong ChenHaojie RaoErli ZhangHongyue WangFei ChuXuan NingXuejian YangJinqing YuanYongjian WuYu HuangShengshou HuDe-Pei LiuMiao WangPublished in: Circulation research (2022)
PDE4B is critically involved in neutrophil inflammation and microvascular obstruction, leading to MI/R injury. Selective inhibition of PDE4B might protect cardiac function in patients with acute myocardial infarction designated for reperfusion therapy.