Long-term reliability of the phospholamban (PLN) p.(Arg14del) risk model in predicting major ventricular arrhythmia: a landmark study.

Myrthe Y C van der Heide Tom E Verstraelen Freyja H M van Lint Laurens P Bosman Remco de Brouwer Virginnio M Proost Esmée van Drie Karim Taha Aeilko H ZwindermanCathelijne DickhoffBas A SchoonderwoerdTjeerd Germans Arjan C Houweling Juan Ramon Gimeno-Blanes Paul A van der Zwaag Rudolf A de Boer Moniek G P J Cox van J Peter Tintelen Arthur A M Wilde

Published in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2024)

The PLN p.(Arg14del) risk model has sustained good model performance up to 3 years follow-up in PLN p.(Arg14del)-positive subjects with no history of major VA. It may therefore be used to support decision-making for primary prevention ICD implantation not merely at presentation but also up to at least 3 years of follow-up.

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