The Selective NLRP3-inflammasome inhibitor MCC950 Mitigates Post-resuscitation Myocardial Dysfunction and Improves Survival in a Rat Model of Cardiac Arrest and Resuscitation.

Guanghui ZhengFenglian HeJing XuJuntao HuWeiwei GeXianfei JiChangsheng WangJennifer L BradleyMary Ann PeberdyJoseph P OrnatoLongyuan JiangStefano ToldoTong WangWanchun Tang

Published in: Cardiovascular drugs and therapy (2022)

Administration of MCC950 following ROSC mitigates post-resuscitation myocardial dysfunction and improves survival.

Keyphrases

cardiac arrest
nlrp inflammasome
cardiopulmonary resuscitation
left ventricular
oxidative stress
free survival
heart failure
radiation therapy
atrial fibrillation