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Detection of Circulating Tumor Cells in Cerebrospinal Fluid of Patients with Suspected Breast Cancer Leptomeningeal Metastases: A Prospective Study.

Amélie DarlixLaure CayrefourcqStéphane PouderouxNicolas Menjot de ChampfleurAlexis BievelezWilliam JacotCristina LeahaSimon ThezenasCatherine Alix-Panabières
Published in: Clinical chemistry (2022)
The clinical sensitivity of CTC detection in CSF with the CellSearch® system for LM diagnosis is higher than that of CSF cytology. CTC detection in patients with negative cytology, however, must be further investigated. The finding of HER2+ CTCs in patients with HER2- BC suggests that the HER2 status of LM should be evaluated to increase the treatment opportunities for these patients.
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