Detection of Circulating Tumor Cells in Cerebrospinal Fluid of Patients with Suspected Breast Cancer Leptomeningeal Metastases: A Prospective Study.
Amélie DarlixLaure CayrefourcqStéphane PouderouxNicolas Menjot de ChampfleurAlexis BievelezWilliam JacotCristina LeahaSimon ThezenasCatherine Alix-PanabièresPublished in: Clinical chemistry (2022)
The clinical sensitivity of CTC detection in CSF with the CellSearch® system for LM diagnosis is higher than that of CSF cytology. CTC detection in patients with negative cytology, however, must be further investigated. The finding of HER2+ CTCs in patients with HER2- BC suggests that the HER2 status of LM should be evaluated to increase the treatment opportunities for these patients.
Keyphrases
- circulating tumor cells
- cerebrospinal fluid
- loop mediated isothermal amplification
- circulating tumor
- real time pcr
- end stage renal disease
- label free
- fine needle aspiration
- high grade
- ejection fraction
- newly diagnosed
- chronic kidney disease
- small cell lung cancer
- mass spectrometry
- ultrasound guided
- brain metastases
- quantum dots