Whole-genome single nucleotide polymorphism-based linkage analysis in spondyloarthritis multiplex families reveals a new susceptibility locus in 13q13.

Félicie CostantinoEmmanuel ChaplaisTifenn LeturcqRoula Said-NahalAriane LeboimeElena ZinovievaDiana ZelenikaIvo GutCéline CharonGilles ChiocchiaMaxime BrebanHenri-Jean Garchon

Published in: Annals of the rheumatic diseases (2015)

We report here for the first time a significant linkage between 13q13 and SpA. Identification of susceptibility factor inside this chromosomal region through targeted sequencing in linked families is underway.

Keyphrases

genome wide
single cell
ankylosing spondylitis
disease activity
cancer therapy
rheumatoid arthritis
gene expression
dna methylation
high density
human immunodeficiency virus