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Whole-genome single nucleotide polymorphism-based linkage analysis in spondyloarthritis multiplex families reveals a new susceptibility locus in 13q13.

Félicie CostantinoEmmanuel ChaplaisTifenn LeturcqRoula Said-NahalAriane LeboimeElena ZinovievaDiana ZelenikaIvo GutCéline CharonGilles ChiocchiaMaxime BrebanHenri-Jean Garchon
Published in: Annals of the rheumatic diseases (2015)
We report here for the first time a significant linkage between 13q13 and SpA. Identification of susceptibility factor inside this chromosomal region through targeted sequencing in linked families is underway.
Keyphrases
  • genome wide
  • single cell
  • ankylosing spondylitis
  • disease activity
  • cancer therapy
  • rheumatoid arthritis
  • gene expression
  • dna methylation
  • high density
  • human immunodeficiency virus