The unpredictable resorption of bioresorbable scaffolds-A tale of two ABSORBs.
Akshyaya PradhanShubhajeet RoyMonika BhandariPravesh VishwakarmaMarco Alfonso PerroneRishi SethiOmer Ahmed ShaikhPublished in: Clinical case reports (2024)
Bioresorbable stents represent a revolutionary treatment for coronary artery disease. Such a device offers the prospect for complete naturalization of artery lumen after strut resorption and restoration of vasomotion while curtailing the duration of dual anti-platelet therapy. The prototype bioresorbable scaffold (BRS-ABSORB GT1) demonstrated good feasibility and safety in the initial studies compared to metallic drug eluting stent but later fell out of favor due to multiple report of stent thrombosis and target lesion failure. Unpredictable resorption of struts turned out to be one of the "Achilles heel" of the BRS and stent strut were still visible in vessel on optical coherence tomography (OCT) at 3 years. We report a case of differential resorption of two ABSORB BRS implanted simultaneously in the same patient by the same operator. Follow up coronary angiogram revealed only minimal plaques on right coronary artery (RCA) and left anterior descending artery (LAD). The BRS were identified on cine-angiogram by their radio-opaque markers at both ends. The OCT run in LAD artery revealed "ghost remnants" of BRS struts in LAD, whereas the RCA BRS had completely healed with minimal "ghost" struts. The ghost remnants of BRS resembled the original "Check box" appearance on OCT during the index implantation.
Keyphrases
- optical coherence tomography
- coronary artery
- coronary artery disease
- diabetic retinopathy
- stress induced
- stem cells
- pulmonary embolism
- single cell
- heart failure
- type diabetes
- case report
- cardiovascular disease
- percutaneous coronary intervention
- cardiovascular events
- binding protein
- ultrasound guided
- combination therapy
- bone marrow
- pulmonary arterial hypertension
- transcatheter aortic valve replacement