An MRI evaluation of white matter involvement in paradigmatic forms of spastic ataxia: results from the multi-center PROSPAX study.
Alessandra ScaravilliIlaria GabusiGaia MariMatteo BattocchioSara BosticardoSimona SchiaviBenjamin BenderChristoph KesslerBernard BraisRoberta La PianaBart P van de WarrenburgMirco CosottiniDagmar Timmannnull nullAlessandro DaducciRebecca SchüleMatthis SynofzikFilippo Maria SantorelliSirio CocozzaPublished in: Journal of neurology (2024)
In ARSACS, but not SPG7 patients, we observed a complex and multi-faced involvement of brain WM, with a clinically meaningful widespread loss of axonal and dendritic integrity, secondary demyelination and, overall, a reduction in cellularity and volume.
Keyphrases
- white matter
- end stage renal disease
- chronic kidney disease
- ejection fraction
- newly diagnosed
- magnetic resonance imaging
- spinal cord injury
- peritoneal dialysis
- prognostic factors
- magnetic resonance
- contrast enhanced
- early onset
- computed tomography
- cerebral palsy
- optical coherence tomography
- functional connectivity
- subarachnoid hemorrhage
- patient reported
- optic nerve