Mild Hypercapnia or Normocapnia after Out-of-Hospital Cardiac Arrest.
Glenn EastwoodAlistair D NicholCarol L HodgsonRachael L ParkeShay McGuinnessNiklas NielsenStephen BernardMarkus B SkrifvarsDion StubFabio S TacconeJohn ArcherDemetrios KutsogiannisJosef DankiewiczGisela LiljaTobias CronbergHans KirkegaardGilles CapellierGiovanni LandoniJanneke HornTheresa OlasveengenYaseen ArabiYew Woon ChiaAndrej MarkotaMatthias HænggiMatt P WiseAnders M GrejsSteffen ChristensenHeidi Munk-AndersenAsger GranfeldtGeir Ø AndersenEirik QvigstadArnljot FlaaMatthew ThomasKatie SweetJeremy BewleyMinna BäcklundMarjaana TiainenManuela ItenAnja LevisLeah PeckJames WalshamAdam DeaneAngajendra GhoshFilippo AnnoniYan ChenDavid KnightEden LesonaHaytham TlayjehFranc SvenšekPeter J McGuiganJade ColeDavid PogsonMatthias Peter HiltyJoachim Pascal DüringMichael J BaileyEldho PaulBridget AdyKate AinscoughAnna HuntSinéad MonahanTony TrapaniCiara FaheyRinaldo Bellomonull nullPublished in: The New England journal of medicine (2023)
In patients with coma who were resuscitated after out-of-hospital cardiac arrest, targeted mild hypercapnia did not lead to better neurologic outcomes at 6 months than targeted normocapnia. (Funded by the National Health and Medical Research Council of Australia and others; TAME ClinicalTrials.gov number, NCT03114033.).