Bufotenine, a tryptophan-derived alkaloid, suppresses the symptoms and increases the survival rate of rabies-infected mice: the development of a pharmacological approach for rabies treatment.

Hugo VigerelliJuliana M ScianiPatricia M C PereiraAline A LavezoAndrea C R SilvaRita C O CollaçoThalita RochaThais C BuenoDaniel Carvalho Pimenta

Published in: The journal of venomous animals and toxins including tropical diseases (2020)

Bufotenine is a promising candidate for drug development. After further chemical modification, it might be possible to dissociate minor side effects, increase efficiency, efficacy and pharmacokinetics, yielding a true anti-rabies drug.

Keyphrases

signaling pathway
type diabetes
emergency department
metabolic syndrome
sleep quality
physical activity
adipose tissue
depressive symptoms
combination therapy
free survival
adverse drug