Neddylation Inactivation Facilitates FOXO3a Nuclear Export to Suppress Estrogen Receptor Transcription and Improve Fulvestrant Sensitivity.

Xiaoqing JiaChunjie LiLihui LiXiaoli LiuLisha ZhouWenjuan ZhangShuaishuai NiYun LuLi ChenLak Shin JeongJinha YuYingjian ZhangJianping ZhangSimin HeXin HuHefen SunGuangyu LiuHu ZhaoYanmei ZhangLijun JiaZhi-Ming Shao

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

Our proof-of-principle study determines the activation of neddylation in breast tumor tissues for the first time and reveals a new ER-α regulatory mechanism, as well as further explores an effective approach to improve fulvestrant sensitivity through a neddylation inactivation combination.

Keyphrases

estrogen receptor
transcription factor
metastatic breast cancer
gene expression
cell proliferation
pi k akt
endoplasmic reticulum