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Small-molecule antagonism of the interaction of the RAGE cytoplasmic domain with DIAPH1 reduces diabetic complications in mice.

Michaele B ManigrassoPiul S RabbaniLander Egaña-GorroñoNosirudeen QuadriLaura FryeBoyan ZhouSergey ReverdattoLisa-Marie RamirezStephen DansereauJinhong PanHuilin LiVivette D D'AgatiRavichandran RamasamyRobert J DeVitaAlexander ShekhtmanAnn Marie Schmidt
Published in: Science translational medicine (2021)
[Figure: see text].
Keyphrases
  • small molecule
  • protein protein
  • high fat diet induced
  • type diabetes
  • smoking cessation
  • wound healing
  • risk factors
  • wild type
  • metabolic syndrome
  • insulin resistance
  • adipose tissue