N1-methylnicotinamide (MNAM) as a guardian of cardiovascular system.
Hamid Reza NejabatiAynaz MihanfarMasoud PezeshkianAmir FattahiZeinab LatifiNaser SafaieMohammad ValilooAhmad Reza JodatiMohammad NouriPublished in: Journal of cellular physiology (2018)
Atherosclerosis is identified as the formation of atherosclerotic plaques, which could initiate the formation of a blood clot in which its growth to coronary artery can lead to a heart attack. N-methyltransferase (NNMT) is an enzyme that converts the NAM (nicotinamide) to its methylated form, N1-methylnicotinamide (MNAM). Higher levels of MNAM have been reported in cases with coronary artery disease (CAD). Further, MNAM increases endothelial prostacyclin (PGI2) and nitric oxide (NO) and thereby causes vasorelaxation. The vasoprotective, anti-inflammatory and anti-thrombotic roles of MNAM have been well documented; however, the exact underlying mechanisms remain to be clarified. Due to potential role of MNAM in the formation of lipid droplets (LDs), it might exert its function in coordination with lipids, and their targets. In this study, we summarized the roles of MNAM in cardiovascular system and highlighted its possible mode of actions.
Keyphrases
- coronary artery disease
- coronary artery
- nitric oxide
- anti inflammatory
- cardiovascular disease
- heart failure
- pulmonary arterial hypertension
- cardiovascular events
- endothelial cells
- type diabetes
- risk assessment
- nitric oxide synthase
- density functional theory
- climate change
- pulmonary hypertension
- transcatheter aortic valve replacement
- left ventricular
- ejection fraction