Krüppel-like factor-4 and Krüppel-like factor-2 are important regulators of joint tissue cells and protect against tissue destruction and inflammation in osteoarthritis.

Manabu KawataTakeshi TeramuraPhilip OrdoukhanianSteven R HeadPadmaja NatarajanAishwarya SundaresanMerissa OlmerHiroshi AsaharaMartin K Lotz

Published in: Annals of the rheumatic diseases (2022)

KLF4 and KLF2 may be central transcription factors that increase protective and regenerative functions in joint tissue cells, suggesting that KLF gene transfer or molecules upregulating KLFs are therapeutic candidates for OA.

Keyphrases

transcription factor
induced apoptosis
cell cycle arrest
stem cells
oxidative stress
mesenchymal stem cells
rheumatoid arthritis
knee osteoarthritis
endoplasmic reticulum stress
signaling pathway
cell death
genome wide identification
dna methylation
dna binding
copy number
gene expression